Garfield is a fat, lazy orange cat, who wants nothing more out of life than to eat and sleep. He loves to eat his favorite lasagna, takes care of his teddy bear named Pooky, and sometimes the audience hear Garfield's thoughts while his mouth doesn't move. His owner Jon Arbuckle is a bachelor cartoonist who has poor luck with women, sometimes often annoyed by some of Garfield's antics, and has a love interest named Liz Wilson who is a veterinarian. Garfield's best friend Odie is a yellow dog who communicates with body language and it makes Garfield understand what he says. Arlene is Garfield's on-and-off girlfriend who can successfully crack jokes at the expense Garfield regularly. In the 2004 live-action version of Garfield, he is voiced by Bill Murray and he must rescue Odie from the Chapman while Odie is being abducted. Jon is played by Breckin Meyer and Dr. Liz Wilson is played by Jennifer Love Hewitt. Followed by Garfield: A Tail of Two Kitties in 2006, Jon plans to marry Liz in London while Garfield confront Prince XII, who looks like Garfield, and is voiced by Tim Curry.
The cartoon series features the voices of Lorenzo Music as Garfield. Thom Huge as Jon Arbuckle. Gregg Berger as Odie. Desiree Goyette as Nermal.